01
Cognitive health
Does L-ergothioneine support memory or cognitive function?
Two small-to-moderate randomized trials and prospective observational cohorts are under adversarial review.
Human review in progressRead the draft review
Claimed Benefits Registry
L-Ergothioneine Benefits: Claimed Benefits vs. Scientific Evidence
A public map of what is claimed, why each claim is being reviewed, and whether the evidence review is complete. An unfinished review receives no evidence rating.
10 principal domains9 preliminary profiles1 human review in progress0 final rulings
Principal reviews
Ten benefit domains
Completed pages will show direction, evidence stage, certainty, and the language the evidence permits.
02
Sleep
Does L-ergothioneine improve sleep?
Controlled studies with sleep-related measures have been identified; outcome priority, clinical importance, and replication remain under review.
Preliminary evidence mappingView preliminary evidence profile
03
Healthy aging
Does L-ergothioneine support healthy aging or longevity?
Human associations and preclinical lifespan findings are mapped separately; no human longevity effect is established.
Preliminary evidence mappingView preliminary evidence profile
04
Cellular protection
Does L-ergothioneine protect cells from oxidative damage?
Transport, mechanistic, and biomarker evidence is being mapped without treating plausibility as a clinical outcome.
Preliminary evidence mappingView preliminary evidence profile
05
Cardiovascular health
Does L-ergothioneine support heart or vascular health?
Claim variants and the evidence needed to test them are mapped; no efficacy verdict has been assigned.
Preliminary evidence mappingView preliminary evidence profile
06
Metabolic health
Does L-ergothioneine affect blood sugar or metabolic health?
Glucose, insulin, lipid, and disease claims are separated while primary-source collection remains incomplete.
Preliminary evidence mappingView preliminary evidence profile
07
Skin health
Does L-ergothioneine benefit skin or protect against photoaging?
A mushroom-product trial is mapped with attribution limits; oral, topical, and mechanistic evidence remain separate.
Preliminary evidence mappingView preliminary evidence profile
08
Exercise and recovery
Does L-ergothioneine improve exercise performance or recovery?
Performance, recovery, soreness, fatigue, and biomarker claims are mapped without an efficacy verdict.
Preliminary evidence mappingView preliminary evidence profile
09
Liver health
Does L-ergothioneine benefit or protect the liver?
Preclinical protection, liver-marker, disease, and “detox” claims are separated while human evidence is collected.
Preliminary evidence mappingView preliminary evidence profile
10
Inflammation and immune health
Does L-ergothioneine reduce inflammation or support immune health?
Biomarker, immune-function, infection, and disease claims are mapped as distinct questions.
Preliminary evidence mappingView preliminary evidence profile
Emerging topics
Other claims being monitored
These topics are inventoried without a dedicated public page. A page will be created only when the evidence or public interest supports a useful, substantive review.
Eye healthKidney healthGut healthReproductive healthCancer protectionMood and stress resilience
Not benefit claims
Safety, dosage, absorption, and bioavailability
These questions are important, but they do not demonstrate a benefit. They are evaluated separately so that tolerability, blood-level changes, or a dose used in research are not mistaken for proof of efficacy.
Review safety and side effects · Review dosage evidence · Inspect the study database