Verified research record · Preclinical
Ergothioneine promotes longevity and healthy aging in male mice
Ahn Y et al. · GeroScience · 2024
- Population
- Male mice and C. elegans
- Participants
- 36 treated mice; 35 controls
- Intervention
- Approximately 4–5 mg/kg/day in drinking water
- Duration
- Lifelong exposure in mice
- Topics
- Animal, Aging, Cognitive
- PMID
- 38446314
- DOI
- 10.1007/s11357-024-01107-5
Key finding
Treated male mice lived longer and showed differences in frailty, movement and learning measures.
Important limitations
Animal findings do not establish lifespan or healthy-aging effects in humans; one sex studied in mice.
Editorial interpretation
Compelling preclinical evidence and a reason to study humans—not proof of human longevity benefit.
Funding and conflicts
See the publication’s complete funding and conflict disclosures.