Verified research record · Human RCT
Effects of an ergothioneine-rich Pleurotus sp. on skin moisturizing functions and facial conditions: a randomized, double-blind, placebo-controlled trial
Hanayama M et al. · Frontiers in Medicine · 2024
- Population
- Healthy women
- Participants
- 80
- Intervention
- Pleurotus tablets providing 25 mg ergothioneine/day
- Duration
- 12 weeks
- Topics
- Human, Skin
- PMID
- 38887673
- DOI
- 10.3389/fmed.2024.1396783
Key finding
The study reported between-group differences for selected skin-moisture and imaging outcomes at certain time points.
Important limitations
Multiple outcomes and time points; mushroom matrix rather than isolated ergothioneine; some authors were employed by the mushroom producer.
Editorial interpretation
An interesting product-specific trial that needs independent replication before broad skin claims.
Funding and conflicts
Three authors were salaried employees of Hokuto Corporation, which cultivated mushrooms used in the study.