Verified research record · Human observational
Serum ergothioneine and risk of dementia in a general older Japanese population: the Hisayama Study
Meng X et al. · Psychiatry and Clinical Neurosciences · 2025
- Population
- Community-dwelling Japanese adults aged 65+ without dementia at baseline
- Participants
- 1,344
- Intervention
- No intervention; baseline serum ergothioneine
- Duration
- Median 11.2 years
- Topics
- Human, Cognitive, Aging
- PMID
- 40908798
- DOI
- 10.1111/pcn.13893
Key finding
Higher serum ergothioneine was associated with lower incidence of all-cause dementia, Alzheimer’s disease, and non-Alzheimer dementia after multivariable adjustment.
Important limitations
Observational exposure cannot establish causation or show that supplementation prevents dementia; residual confounding and reverse causation remain possible.
Editorial interpretation
A substantial prospective association that strengthens the research rationale without proving a preventive supplement effect.
Funding and conflicts
Several authors were affiliated with Suntory Global Innovation Center; consult the paper for the complete funding and conflict disclosures.